FIELD: biotechnology, genetic engineering. SUBSTANCE: recombinant plasmid DNA puR2N in which gene duplication encoding tick-borne encephalitis virus protein NS1 short form is carried out encodes the synthesis of tick-borne encephalitis virus protein NS1 short form in E.coli cells. DNA puR2N is constructed on the basis of large Eco RI-fragment of vector plasmid puR290 (size is 5.1 thousand nucleotide pairs), SalI -AluI (3521)-fragment of plasmid puC18SE containing encoding gene sequence for tick-borne encephalitis virus protein NS1 short form and two synthetic DNA fragments (size is 21 and 9 thousand nucleotides pairs, respectively). Invention can be used in microbiological industry and medicine for development of highly effective prophylaxis and diagnostic agents for struggle against tick-borne encephalitis. EFFECT: construction of recombinant DNA plasmid indicated above. 3 cl
| Title |
Year |
Author |
Number |
| RECOMBINANT PLASMID DNA PUR 290 SΔE ENCODING HYBRID POLYPEPTIDE β-GALACTOSIDASE-NS 1 - A PROTEIN OF MITE ENCEPHALITIS VIRUS, AND A METHOD OF ITS CONSTRUCTION |
1989 |
- Pugachev K.V.
- Pletnev A.G.
- Jamshchikov V.F.
- Gorn V.V.
|
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1995 |
- Gajnullina M.N.
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- Ignat'Ev G.M.
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- Belyaev A.S.
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|
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- Tereza Kabezon
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|
SU1746887A3 |
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1992 |
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1993 |
- Garaev M.M.
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|
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0 |
- Rubtsov Petr Mikhajlovich
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- Gorbulev Valentin Grigorevich
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