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2 112 038

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IPC

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Application

95118749/13, 1995-11-02

(22)

Actual filing date

1995-11-02

(45)

Published

1998-05-27

(72)

Inventor

Gajnullina M.N.Dmitriev I.P.Dobrikova E.Ju.Khromykh A.A.Ignat'Ev G.M.Pugachev K.V.Ageenko V.A.Vorob'Eva M.S.Pletnev A.G.Beljaev A.S.Sandakhchiev L.S.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

RECOMBINANT PLASMID DNA PC-NS3 PROVIDING INTEGRATION OF COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS 2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN GENOME OF BOVINE VACCINE VIRUS AND RECOMBINANT STRAIN OF BOVINE VACCINE VIRUS EXPRESSING COMPLEX OF GENES C, PRM, E, NS1, NS 2A, NS2B, NS3 OF TICK-BORNE ENCEPHALITIS VIRUS IN IMMUNIZED ORGANISM CELLS Russian patent published in 1998 - IPC

Abstract RU 2112038 C1

FIELD: biotechnology, genetic engineering. SUBSTANCE: invention relates to preparing recombinant plasmid DNA pC-NS3 providing integration of complex of genes C, prM, E, NS1, NS 2A, NS 2B, NS 3 of tick-borne encephalitis virus in genome of bovine vaccine virus and the corresponding strain of the latter. Plasmid has also promoter p7, 5K bovine vaccine virus, synthetic DNA-fragments with initiation sites and translation termination and the DNA sequence of thymidine kinase gene of bovine vaccine virus. Obtained plasmid DNA pC-NS3 is used for incorporation of complex of genes C-NS3 of tick-borne encephalitis virus in genome of bovine vaccine virus. Recombinant bovine vaccine virus in cells of immunized organism provides expression of complex of tick-borne encephalitis virus that promotes the formation of protective immunity against infection with tick-borne encephalitis virus. EFFECT: recombinant plasmid preparing. 2 cl, 1 tbl, 1 dwg

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RU 2 112 038 C1

Authors

Gajnullina M.N.

Dmitriev I.P.

Dobrikova E.Ju.

Khromykh A.A.

Ignat'Ev G.M.

Pugachev K.V.

Ageenko V.A.

Vorob'Eva M.S.

Pletnev A.G.

Beljaev A.S.

Sandakhchiev L.S.

Dates

1998-05-27—Published

1995-11-02—Filed