METHOD OF DETERMINING EXTENT OF INTOXICATION OF ORGANISM Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: patient's blood serum freed from hemagglutinins was admixed with system to be tested, that is, rat's erythrocytic mass enriched by reticulocytes by preliminary bloodletting. Resultant admixture was incubated after which smears were prepared from erythrocytic suspension and then colored. Researchers calculated number of reticulocytes (P ) in terms of promils and arrived at conclusion that organism should be regarded as actually intoxicated if P value is above 40 % . Disclosed method is highly sensitive, specific and easy-to-carry out and requires less time. Hence, it may well be used both in clinical and ambulatory conditions. EFFECT: higher effectiveness of assessing blood serum toxicity owing to higher sensitivity and specificity, simpler techniques and shorter time required for investigation. 1 tbl