DERIVATIVES OF PENTAPEPTIDES Russian patent published in 1994 - IPC

FIELD: biochemistry, medicine. SUBSTANCE: products: pentapeptides of the general formula I , where X₁, X₂ and X₃ mean independently OH or NH₂ under condition that X₂ and X₃ both do not mean NH₂. To synthesize compounds of the general formula I classic methods of peptide synthesis are used: in solution, on the solid phase following by removal of protected groups from amino-, amido, hydroxyl- and/or carboxyl. Synthesized compounds show capability to inhibit the growth of liver cells, they do not show any toxicity. EFFECT: improved method of synthesis. 6 tbl