METHOD OF SYNTHESIS OF δ-SLEEP PEPTIDE Russian patent published in 1998 - IPC

Abstract RU 2111972 C1

FIELD: chemistry of peptides, medicinal chemistry. SUBSTANCE: method relates to the improved method of synthesis of δ-sleep peptide: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (I). Method involves condensation of pentafluorophenyl ester of Boc-protected tetrapeptide Boc-Trp-Ala-Gly-Gly-OPfp (II) c pentapeptide Asp-Ala-Ser-(X)-Gly-Glu (III) where X - acetyl or formyl in dimethylformamide in the presence of N-methylmorpholine followed by removal of Boc-group with formic acid at (-2)-(+8) C and acetyl or formyl group at alkaline condition and purification of the end product by chromatography. δ-Sleep peptide shows homogeneity (by TLC data), yield is 65-80%. EFFECT: improved method of synthesis, broad spectrum of physiological activity. 2 tbl, 1 dwg

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RU 2 111 972 C1

Authors

Bezrukov M.V.

Panchenko A.E.

Prudchenko I.A.

Mikhaleva I.I.

Ivanov V.T.

Dates

1998-05-27—Published

1995-04-07—Filed