FIELD: chemistry of peptides. SUBSTANCE: invention relates to improved method of synthesis of peptide of $$$-sleep Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (I). Method involves condensation of pentafluorophenyl ester of Boc-protected tetrapeptide Boc-Trp-Ala-Gly-Gly-OPfp (II) with pentapeptide Asp-Ala-Ser-Gly-Glu (III) in dimethylformamide in the presence of N-methylmorpholine followed by removal of Boc-group with formic acid at (-2)-(+8) C and purification of the end product by chromatography. The end product shows homogeneity by data of TLC. The yield of $$$-sleep peptide is 70-80%. Peptide elicits broad spectrum of physiological activity. EFFECT: improved method of peptide synthesis. 1 dwg
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