AMINONAPHTHALENESULFAMIDE DERIVATIVES AS SUBSTRATES FOR DETERMINING ACTIVE PROTEIN WITH APC ENZYME Russian patent published in 1994 - IPC

Abstract RU 2013426 C1

FIELD: bioorganic chemistry. SUBSTANCE: the invention resides in that new substrates are rapidly hydrolyzed with the APC enzyme and slowly with a thrombin. The time period pf their 10% hydrolysis with the APC enzyme is by 830-180 times shorter than that with a thrombin. To prove the presence of the positive effect, the Michael-Menten constants K_м and the catalytic constant K_cat are calculated, and the claimed compounds which are superior by ~ 10³ times over the prior art are determined by the ratio value of these constants. Said properties make it possible to use them as substrates for the determination of the ASPC enzyme producing rate by activating protein C with a thrombin. EFFECT: increased selectivity. 6 tbl, 3 dwg

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RU 2 013 426 C1

Authors

Butenas S.Ju.

Palajma A.I.

Bljum R.A.

Talajkite Z.A.

Dates

1994-05-30—Published

1991-03-19—Filed