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2 054 001

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IPC

(21) (22)

Application

4854375/04, 1990-07-20

(22)

Actual filing date

1990-07-20

(45)

Published

1996-02-10

(72)

Inventor

Palajma Al'Girdas Ionovich[Lt]Butenas Sauljus Juozovich[Lt]Nedospasov Andrej Arturovich[Ru]

(73)

Holder

Institut Biokhimii Litovskoj AnInstitut Molekuljarnoj Genetiki Ran

METHOD OF SYNTHESIS OF 5-ARGINYLAMINONAPHTHALENE-1-SULFAMIDES Russian patent published in 1996 - IPC

Abstract RU 2054001 C1

FIELD: organic chemistry. SUBSTANCE: product: 5-arginylaminonaphthalene-1-sulfamides of the formula where R₁=H; R₂=CH₃, C₂H₅, C₃H₇, iso-C₃H₇, C₄H₉, iso-C₄H₉, C₅H₁₁, C₆H₁₁; R₁=R₂=CH₃, C₂H₅, NR₁R₂ together ; empirical formulas are БФ C₂₁H₃₀N₆SO₃, C₁₇H₂₄N₆SO₃, C₁₈H₂₆N₆SO₃. Reagent 1: N^α-tert.-butylhydroxycarbonylarginyl hydrochloride (HCl). Reagent 2: 5-aminonaphthalene-1-sulfamide. Reaction conditions: in the medium of dimethylformamide (DMFA) and pyridine, in the presence of di-tert.-butylpyrocarbonate followed by protecting group removal. EFFECT: improved method of synthesis. 3 cl, 3 tbl

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RU 2 054 001 C1

Authors

Palajma Al'Girdas Ionovich[Lt]

Butenas Sauljus Juozovich[Lt]

Nedospasov Andrej Arturovich[Ru]

Dates

1996-02-10—Published

1990-07-20—Filed