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2 043 337

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IPC

(21) (22)

Application

4854378/04, 1990-07-20

(22)

Actual filing date

1990-07-20

(45)

Published

1995-09-10

(72)

Inventor

Butenas Sauljus Juozovich[Lt]Palajma Al'Girdas Ionovich[Lt]Nedospasov Andrej Arturovich[Ru]Baranauskas Gintaras Justovich[Lt]

(73)

Holder

Institut Biokhimii Litovskoj An

METHOD OF SYNTHESIS OF 5-ARGINYLAMINONAPHTHALENE-1-SULFAMIDES Russian patent published in 1995 - IPC

Abstract RU 2043337 C1

FIELD: organic chemistry. SUBSTANCE: process is carried out by interaction of N_q-nitro-N_α-tert. -butylhydroxycarbonylarginine with 5-amino-naphthalene-1-sulfamide in the form of base in pyridine and dioxane medium in the presence of di-tert.-butylpyrocarbonate, and compound is obtained where values R¹, R² are given above. Protective groups were removed with hydrogen in hydrogen chloride solution in methanol in the presence of Pd/C. Method provides yield increase from 35-40% to 49-62.7% EFFECT: increased yield of product. 7 tbl

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RU 2 043 337 C1

Authors

Butenas Sauljus Juozovich[Lt]

Palajma Al'Girdas Ionovich[Lt]

Nedospasov Andrej Arturovich[Ru]

Baranauskas Gintaras Justovich[Lt]

Dates

1995-09-10—Published

1990-07-20—Filed