METHOD OF SYNTHESIS OF 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product of the general formula I, CH₃, where R - H, R₁-H, CH₃; -CH₂CH₂-; X - -CH₂-CH₂-CH₂ or R₂-H; C₁-C₃ - H, Hal, C₁-C₃-alkoxy, R₃-H-alkyl; R₄-H - H, Hal; C₁-C₃ - H, Hal, C₁-C₃-alkyl, R₅-H-alkoxy; C₁-C₃ - H, C₁-C₃-alkyl, -alkoxy. Reagent 1: corresponding tetralone 2. Reagent 2: corresponding piperazine or homopiperazine 3. Reaction conditions: product prepared by interaction of compounds 2 and 3 is reduced. New compounds are selective inhibitors of serotonin uptake, which do not show direct effect on neuron receptors. EFFECT: improved method of synthesis. 1 tbl