FIELD: organic chemistry, medicine.
SUBSTANCE: invention relates to novel 2-azaspiro[4.6]undecan-3-thiones of the formula (I): wherein X1 and X2 represent in common =S; R1 means hydrogen atom (H); R2 means H; R3 means H, -RQ2; Z means 5-8-membered monocyclic saturated ring bound through a general C-atom with the first azaheterocyclic ring; R8 means (C1-C5)-alkylcarbonyl; Q2 means H, or its pharmaceutically acceptable salts used as an analgesic agent. This allows their using in treatment of chronic inflammatory and/or neuropathic pain.
EFFECT: valuable medicinal properties of compounds.
17 cl, 1 tbl, 1 dwg, 8 ex
Title | Year | Author | Number |
---|---|---|---|
2-AMINOBENZOTHIAZOLYLUREAS AS ADENOSINE MODULATORS | 2002 |
|
RU2311905C2 |
OXADIAZOLES AS MUSCARINIC RECEPTOR AGONISTS M AND/OR M | 2019 |
|
RU2817018C2 |
HETEROCYCLIC COMPOUNDS | 2019 |
|
RU2809257C2 |
SUBSTITUTED TETRAHYDROPYRANSPIROPYRROLIDINONE AND TETRAHYDROPYRANSPIROPIPERIDINONE, BASED ON THEM PHARMACEUTICAL COMPOSITION AND APPLICATION FOR THERAPEUTIC PURPOSES | 2009 |
|
RU2519778C2 |
TRIAZOLOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2677698C1 |
TETRAHYDROBENZIMIDAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS | 2014 |
|
RU2684637C1 |
ANALGETIC COMPOUND AND ITS PRODUCTION METHOD | 2018 |
|
RU2791108C2 |
NITROXY-DERIVATIVES AND THEIR SALTS, BASED ON THEM PHARMACEUTICAL COMPOSITION AND THEIR APPLICATION AS MEDICATIONS FOR CHRONIC PAIN TREATMENT | 2003 |
|
RU2340598C2 |
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2691629C1 |
BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY | 2014 |
|
RU2677696C1 |
Authors
Dates
2008-04-20—Published
2003-02-27—Filed