FIELD: biotechnology, medicine. SUBSTANCE: method involves conjugation of diacylated lipopolysaccharides of serovara Inaba or Ogava with copolymer N-hydroxyethylenepiperazine and N-acylhydrazide of ethylenepiperazinium bromide by azide method with mol. mass 40 kDa at weight ratio carrier:antigen 4-7:1. Method ensures to prepare harmless vaccine showing high immunity property not causing allergic effect on organism. Vaccine can be used as prophylaxis agent against cholera. EFFECT: improved method of vaccine preparing. 3 tbl
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