FIELD: medicine. SUBSTANCE: method involves conjugation of B-subunit of choleraic toxin with copolymer N-hydroxyethylenepiperazine and N-acylhydrazide of ethylenepiperazinium bromide with mol. mass 40 kDa by azide method at the weight ratio carrier-antigen 3-5:1. Proposed method ensures to prepare harmless vaccine with high immunity property not causing allergic effect on organism. EFFECT: improved method of vaccine preparaing. 3 tbl
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