METHOD OF SYNTHESIS OF IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I) where R₁ and R₂ - H, C₁- C₈-alkyl, C₃- C₈-alkyl with branched chain, C₃- C₇-cycloalkyl, 2-, 3- or 4-pyridinyl, 2-thienyl, 2-furanyl, phenyl. The latter in some cases can be substituted with 1-3 groups taken from F, Cl, Br, OH, C₁- C₄-alkoxy, C₁- C₄-alkyl, CH₃S(O)₂, CF₃ or NR₇R₈, or R₁ and R₂ taken together form the group of the formula (II) where L-O, O(CH₂)O; R₃-H, C₁-C₆-alkyl or phenyl; Z-NHR₄, R₄ , OR₄; R₄-C₁-C₈-alkyl with normal chain, C₃-C₈-alkyl with branched chain, C₃-C₇-cycloalkyl, C₄-C₁₀-cycloalkylalkyl, C₇-C₁₄-aralkyl where aryl-group in some cases is substituted with 1-3 groups. The latters are taken from the row consisting of C₁-C₄-alkyl, phenyl which in some cases is substituted with 1-3 groups taken from the following row: C₁-C₄-alkyl, phenyl substituted in some cases with 1-5 groups taken from the row consisting of C₁-C₄-alkyl, C₁-C₄-alkoxy, F, CN, Cl, pentafluorophenyl, and benzyl. The latter in some cases is substituted with 1-3 groups taken from the row consisting of C₁-C₄-alkyl, F, Cl, 2-pyridinium; R₅-H, C₁-C₉-alkyl, NR₇R₈, benzyl, C₃-C₈-alkyl with the branched chain or phenyl. The latter in some cases is substituted with 1-3 groups taken from the row involving C₁-C₄ - alkyl or - alkoxy, or F; R₇ and R₈, weve taken independently from the group consisting of H and C₁-C₄-alkyl; X-S(O)_r or O; A-C₂-C₁₀-alkyl, C₃-C₁₀-alkyl with the branched chain; Y - O, S, H₂, r = 0-2. Reagent 1: compound of the formula (III) . Reagent 2: compound of the formula (IV) where M - halide, the rest radicals - as indicated above. EFFECT: improved method of synthesis of compounds indicated above.