FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to derivatives of butyric acid of the formula (I): wherein A means carboxyl or (C6-C18)-alkoxycarbonyl; B means ethylene group -CH2-CH2-; R1 means benzyl optionally substituted in phenyl ring, optionally substituted phenyl or optionally substituted pyridyl; Z represents sulfur (S) or selenium (Se) atom; n means a whole number = 0, 1 or 2; R2 represents radical chosen from optionally substituted phenyl, optionally substituted benzopyridine, optionally substituted benzothiazole, optionally substituted quinolyl, optionally substituted naphthyl, optionally substituted triazole and radical of the formula: Also, invention describes methods for synthesis of compounds of the formula (I) and pharmaceutical composition based on thereof. Compound can be used in preparing a medicine designated for treatment or prophylaxis of dyslipidemia and diabetes mellitus.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
9 cl, 1 tbl, 81 ex
Title | Year | Author | Number |
---|---|---|---|
DIHYDROBENZODIAZEPINES, METHODS FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2247115C2 |
BENZOPYRANES AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF AND METHOD FOR THEIR PREPARING | 1999 |
|
RU2228333C2 |
PYRIMIDINE-2,4-DIAMINE DERIVATIVES FOR CANCER TREATMENT | 2013 |
|
RU2672916C2 |
NOVEL NITROMETHYLKETONES, METHOD OF THEIR SYNTHESIS AND COMPOSITIONS COMPRISING THEREOF | 1998 |
|
RU2194046C2 |
DERIVATIVES OF β-CARBOLINE, METHODS FOR PREPARING AND MEDICINAL AGENT | 1999 |
|
RU2210571C2 |
DERIVATIVES OF 3-OXO-1-CYCLOBUTENE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2002 |
|
RU2296753C2 |
5-AMINO-4,6-DISUBSTITUTED INDOLE AND 5-AMINO-4,6-DISUBSTITUTED INDOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS | 2008 |
|
RU2483060C2 |
5-ARYL-1H-1,2,4-TRIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | 2000 |
|
RU2249588C2 |
N-PHENYLAMIDE AND N-PYRIDYLAMIDE DERIVATIVES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | 1998 |
|
RU2214409C2 |
SYMMETRIC AND ASYMMETRIC DERIVATIVES OF DIPHENYLUREA (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF RAF KINASE- MEDIATED TUMOR CELLS PROLIFERATION | 1998 |
|
RU2247109C9 |
Authors
Dates
2007-02-20—Published
2002-07-03—Filed