DERIVATIVES OF BUTYRIC ACID Russian patent published in 2007 - IPC C07C323/62 C07C317/46 C07C391/00 A61K31/192 A61P3/10 

Abstract RU 2293726 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of butyric acid of the formula (I): wherein A means carboxyl or (C6-C18)-alkoxycarbonyl; B means ethylene group -CH2-CH2-; R1 means benzyl optionally substituted in phenyl ring, optionally substituted phenyl or optionally substituted pyridyl; Z represents sulfur (S) or selenium (Se) atom; n means a whole number = 0, 1 or 2; R2 represents radical chosen from optionally substituted phenyl, optionally substituted benzopyridine, optionally substituted benzothiazole, optionally substituted quinolyl, optionally substituted naphthyl, optionally substituted triazole and radical of the formula: Also, invention describes methods for synthesis of compounds of the formula (I) and pharmaceutical composition based on thereof. Compound can be used in preparing a medicine designated for treatment or prophylaxis of dyslipidemia and diabetes mellitus.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

9 cl, 1 tbl, 81 ex

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RU 2 293 726 C2

Authors

Roshe Did'E

Zeje Zhan-Zhak

Kontar Fransis

Gijjar-Dangremon Valeri

Gerr'E Dan'El'

Djupon Ehrve

Bertelon Zhan-Zhak

Dates

2007-02-20Published

2002-07-03Filed