TRICYCLE HETEROCYCLIC COMPOUNDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: TRICYCLE heterocyclic compounds of the general formula (I) where R¹ and R² each means hydrogen, lower alkyl group or halogen atom; R³ means H or lower alkyl group; R⁴ means 1,3-substituted phenyl group and optional can be fused with 5-membered heterocyclic group, for example, furan; R⁵ means H or lower alkyl group; A means lower alkylene group; B means -O- or -S- and n = 0-1. Substituent at phenyl ring is taken from lower alkyl, lower alkoxy-(lower alkyl)-group, lower alkylthio-(lower alkyl)-group, lower alkenyl group, lower alkoxy, phenoxy, benzylhydroxy-group, lower alkylthio, thiophenyl-lower alkoxycarbonyl group, lower alkylsulfinyl group, lower alkylsolfonyl group, halogen atom or nitro-group. Synthesized compounds were used in medicine for treatment or prophylaxis of atherosclerosis. Value JC₅O for the synthesized compounds = 10-65 mg/ml. EFFECT: improved method of synthesis, enhanced effectiveness. 29 cl, 2 tbl