N-PHENYLAMIDE AND N-PYRIDYLAMIDE DERIVATIVES, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, biochemistry, pharmacy. SUBSTANCE: invention relates to novel N-phenylamide and N-pyridylamide derivatives of the formula (I): wherein X means oxygen or sulfur atom; R₁ and R₂ that can be similar or different mean hydrogen atom, (C₁-C₆)-alkyl or (C₃-C₈)- cycloalkyl; or R₁ and R₂ in common with carbon atom to which they are bound form (C₃-C₈)-cycloalkyl; R₃ means (C₆-C₁₂)-aryl optionally substituted with one or some radicals Y that can be similar or different; Y means halogen atom; R₄ and R₅ mean hydrogen atom; Ar means one of the following groups: (B) or (C) ; T means hydrogen atom or (C₁-C₆)-alkyl; T₃ and T₄ that can be similar or different mean (C₁-C₆)- alkyl, (C₁-C₆)-alkoxy-group, (C₁-C₆)-alkylthio-group; R₆ and R₇ each means hydrogen atom; or R₆ and R₇ in common mean a bond; Z means either (I) bivalent group wherein R₉ means hydrogen atom or - alkyl or (II) bivalent group wherein R₁₀ and R₁₁ in common form such bond that Z means group CH= CH-; or R₁₀ and R₁₁ that can be similar or different have values indicated above for R₉; or (III) bivalent group wherein R₁₂ and R₁₃ in common form such bond that Z means CH=CH-; or R₁₂ and R₁₃ that can be similar or different have values indicated above for R₉ as well to its additive salts with pharmaceutically acceptable acid or bases. Invention relates also to method for preparing these compounds, pharmaceutical composition and medicinal agent eliciting hypolipidemic and anti- - atherosclerotic effect based on thereof. These compounds are inhibitors of cholesterol-acyltransferase (ACAT) and can be used in medicine. Invention provides preparing novel N-phenylamide and N- pyridylamide derivatives eliciting valuable biologically active effect. EFFECT: improved preparing method, valuable medicinal properties. 15 cl, 10 tbl, 17 ex