2-PIPERIDINO-1-ALKANOL DERIVATIVES Russian patent published in 1995 - IPC

FIELD: medicinal agents in the treatment of fits or degenerative diseases of the central nervous system. SUBSTANCE: the product: 2-(8-azabicyclo[3,2,1, ] oct-8-yl) alkalones of the formula 1 wherein R is H or C₁-C₃-alkil; Q-group is -S- or CH=CH-; X is H, halogen, OR₁, COOR₁, NH₂, CONH₂ or R₁CONH wherein R₁ is H or C₁-C₃-alkyl; D is a group of formula 2 wherein Y is H; Y¹ is benzyl, unsubstituted or 4-halogen or 4- methoxysubstituted phenylthio or thienylthio where Y¹ is phenyl or benzyl or Y₄, or Y¹ together form a group of the formula CH-C₆H₅ or a group of formula or a group of formula 4 wherein Y² is hydrogen, Y³ is benzyl or (O)_nSC₆H₅ wherein n is O or 2 and where Y² is OH, Y³ is a group of formula 5 wherein m 0,1,2,3 or 4; R₂-H is methyl or halogen or D is a group of formula 6 wherein l is 0 or 1 or L group of formula 7. Reagent 1: 3- phenylmethylene-8-azabicyclo[3,2,1] octane. Reagent 2: 4-(triisopropylsiloxy)-α-bromopropiophenone. Reagent 3: triechylamine. Reaction conditions: heating at reflux. Reagent 4: lithium aluminium hydride. Reaction conditions: in tetrahydrodfuran at room temperature. The structure of formulae 1, 2, 3, 4, 5, 6 and 7: , , , , , . EFFECT: improved properties of the drugs. 17 cl