METHOD OF SYNTHESIS OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4- PHENYLPIPERIDINE-1-YL)-1-PROPANOL MESYLATE TRIHYDRATE AND INTERMEDIATE COMPOUNDS Russian patent published in 2002 - IPC

Abstract RU 2192415 C1

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel method of synthesis of compound mesylate trihydrate of the formula (I) , (1S,2S)-1- (4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidine-1-yl)-1-propanol, by reduction of carbonyl group of (2S)- compound of the formula (II): where R¹ means protective group followed by removal of protective group R¹ from reduced compound. Invention relates to novel compounds of the formula (II) and method of their synthesis also. EFFECT: improved methods of synthesis. 19 cl, 1 tbl

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RU 2 192 415 C1

Authors

Rehjnvill Dzhozef Filip

Sinehj Terri Dzhin Ml.

Valinski Stehnli Uolter

Dates

2002-11-10—Published

2001-04-27—Filed