FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from β-alanine amino-group of which is protected by addition of tert.-butylhydroxycarbonyl-group following by activation of prepared derivative with alkylchloroformate and N-hydroxysuccinimide. N-Tert. -butoxycarbonyl-b-alanine N-hydroxysuccinimide ester is used for acylation of L-histidine in neutral aqueous-organic medium following by isolation of the end product at neutralization at isoelectric point. Under these conditions the yield of the end product is increased from 40 to 50%, m. p. is increased up to 259-263 C, specific rotation is [α]
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