FIELD: organic chemistry. SUBSTANCE: synthesis is carried out from β-alanine amino-group of which is protected by addition of tert.-butylhydroxycarbonyl-group following by activation of prepared derivative with alkylchloroformate and N-hydroxysuccinimide. N-Tert. -butoxycarbonyl-b-alanine N-hydroxysuccinimide ester is used for acylation of L-histidine in neutral aqueous-organic medium following by isolation of the end product at neutralization at isoelectric point. Under these conditions the yield of the end product is increased from 40 to 50%, m. p. is increased up to 259-263 C, specific rotation is [α]
| Title | Year | Author | Number |
|---|---|---|---|
| BIOGENIC AMINE N-ACYL DERIVATIVES ARE MODULATORS OF LIPID PEROXIDE OXIDATION, AND METHOD OF PREPARATION THEREOF | 1994 |
|
RU2093520C1 |
| N,N-DISUCCINIMIDYL SULFITE AS REAGENT FOR SYNTHESIS OF N-OXYSUCCINIMIDE ETHERS OF N-SUBSTITUTED AMINO ACIDS AND PEPTIDES | 0 |
|
SU1068428A1 |
| METHOD OF OBTAINING DODECAPEPTIDE AND TRIPEPTIDE FOR ITS REALISATION | 2007 |
|
RU2340626C1 |
| METHOD OF SOLID-PHASE PEPTIDE SYNTHESIS | 1991 |
|
RU2043362C1 |
| METHOD OF L-CARNOSINE AND ITS HOMOLOGS SYNTHESIS | 1992 |
|
RU2084457C1 |
| N-2-(4-NITROPHENYLSULFONYL)-ETHOXYCARBONYL-AMINO ACIDS AS N-PROTECTED AMINO ACIDS FOR SOLID PHASE SYNTHESIS OF PEPTIDES | 1995 |
|
RU2079491C1 |
| METHOD OF SYNTHESIS OF L-CARNOSINE ESTERS AND THEIR SALTS | 2001 |
|
RU2188204C1 |
| METHOD OF SYNTHESIS OF N-CARBOXYANHYDRIDES OR URETHANE-PROTECTED N-THIOCARBOXYANHYDRIDES | 1989 |
|
RU2007396C1 |
| POLY-N-OXYSUCCINIMIDE ESTERS OF AMINO ACIDS AS REAGENTS FOR PEPTIDE SYNTHESIS | 0 |
|
SU1118636A1 |
| METHOD OF PRODUCING PEPTIDES CONTAINING TYROSINE SULPHATE | 0 |
|
SU920053A1 |
