FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method of synthesis L-carnosine esters and their salts. Method involves interaction of L-carnosine with a lower alcohol in an anhydrous medium of the corresponding alcohol in cooling in the presence of an acidic catalyst followed by isolation and purification of the end substance. All stages are carried out under atmosphere of inert gas using thionyl chloride, hydrogen chloride or sulfuric acid as an acidic catalyst. Method ensures to synthesize the end substances that show high biological activity and enhanced hydrophobicity as compared with that of L-carnosine and the stable yield using carnosine of any origin. EFFECT: improved method of synthesis. 5 cl, 1 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT SHOWING ANTIHYPOXIC AND ANTIOXIDANT ACTIVITY | 2001 |
|
RU2191592C1 |
| 5,5-DISUBSTITUTED 2-METHYL-9,9-DIOXO-9-THIABICYCLO-[4,3,0]NONANES | 2001 |
|
RU2184732C1 |
| METHOD OF PREPARING SODIUM 10-METHYLENE CARBOXYLATE-9-ACRIDONE OR 10- METHYLENECARBOXY-9-ACRIDONE FROM ACRIDONE | 1998 |
|
RU2162843C2 |
| METHOD OF L-CARNOSINE AND ITS HOMOLOGS SYNTHESIS | 1992 |
|
RU2084457C1 |
| BIOGENIC AMINE N-ACYL DERIVATIVES ARE MODULATORS OF LIPID PEROXIDE OXIDATION, AND METHOD OF PREPARATION THEREOF | 1994 |
|
RU2093520C1 |
| METHOD FOR OBTAINING TREPEPTIDE OF GENERAL FORMULA (I) HPyr-His-TrpOH, APPLIED AS INTERMEDIATE COMPOUND (1-3 FRAGMENT) IN SYNTHESIS OF SYNTHETIC AGONISTS OF GONADOTROPIN-RELEASING-HORMONE (LH-RH), BY METHOD OF LIQUID-PHASE PEPTIDE SYNTHESIS WITHOUT PLACING AND REMOVAL OF PROTECTIVE GROUPS | 2014 |
|
RU2574392C1 |
| METHOD OF PREPARING 3-PYRROLINE-2-CABOXYLIC ACID DERIVATIVES | 1997 |
|
RU2199529C2 |
| METHOD OF SYNTHESIS OF CARNOSINE | 1990 |
|
RU2030422C1 |
| OLIGONUCLEOTIDES FOR SUPPRESSION OF PATHOGENIC MICROORGANISMS VITAL ACTIVITY AND METHOD FOR SUPPRESSION OF THEIR VITAL ACTIVITY | 2002 |
|
RU2224524C2 |
| METHOD OF PRODUCING ISOXASOL DERIVATIVES | 0 |
|
SU1493106A3 |
