N-2-(4-NITROPHENYLSULFONYL)-ETHOXYCARBONYL-AMINO ACIDS AS N-PROTECTED AMINO ACIDS FOR SOLID PHASE SYNTHESIS OF PEPTIDES Russian patent published in 1997 - IPC

FIELD:biochemistry,aminoacids,peptides.SUBSTANCE:product:N_α-2-(4-nitrophenylsulfonyl)-ethoxycarbonyl-amino acids: 4-NO₂-C₆H₄-S(O)₂-CH₂-CH₂-O-C(O)-NR₁-CHR₂-COOH where: R₁ - hydrogen; R₂ - hydrogen, methyl, isopropyl, methylpropyl, tert.-butoxymethyl, 1-tert.-butoxyethyl, 2-methylthioethyl, benzyl, carboxamidoalkyl, tert.-butoxycarbonylalkyl, or they form together propylene radical. Yield is up to 86%. Reagent 1: the corresponding amino acid. Reagent 2: 2-(4-nitrophenylsulfonyl)-ethylchloroformate. Reaction conditions: aqueous-organic solvent, in the presence of base, at 0-40 C. Synthesized compounds were used as N_α-protected amino acids for solid phase synthesis of peptides. EFFECT: improved method of synthesis, increased yield. 2 tbl