FIELD: genetic engineering. SUBSTANCE: water-insoluble polypeptide containing fragment of chloroamphenicolacetyltransferase without 10 C-terminal amino acids, amino acid spacer of Sp/n type (where n = 1,2,4 or 8) and amino acid sequence of somatostatin-14 is used as immunostimulator. Immunization of animals with composition consisting of indicated chimeric protein and incomplete Freund adjuvant caused permanent increase of milk yield and/or gain in weight. Productivity increase was a result of specific antisomatostatic immunization and nonspecific effect of stimulation of immunization procedure. The latter can be used for productivity increase in agriculture animals. EFFECT: improved method of productivity increase. 3 cl, 3 tbl
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Authors
Dates
1995-05-10—Published
1993-06-22—Filed