FIELD: chemistry.
SUBSTANCE: invention discloses an injection drug in form of a water-oil suspension of a chimeric protein with water-insoluble enzymatically inactive chloramphenicol acetyltransferase without 10 C-terminal amino acids, amino acid spacer (Sp)n, where n=1, 2, 4, 8, and a somatostatin-14 amino acid sequence AGCFWKTFTSC in refined vegetable oil with addition of apyrogenic water for injection. The invention also relates to a method of increasing human sperm production, which comprises hypodermic injection of said drug twice with an interval of 14-18 days in amount of 50-100 mcg protein per kg body weight.
EFFECT: invention improves reproductive capacity of men by increasing ejaculate volume, sperm count, the percentage of live, active sperm when the injection drug is used with low reactogenicity of the adjuvant, which allows painless injection.
6 cl, 1 tbl
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| METHOD OF PREPARING OF RECOMBINANT PLASMIDS pC(Sp)S ENCODING CHIMERIC PROTEIN WITH SOMATOSTATIN SEQUENCE | 1993 |
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| CHLORAMPHENICOL ACETYL TRANSFERASE (CAT) DEFECTIVE SOMATOSTATIN FUSED PROTEIN AND USING IT | 2008 |
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RU2501565C2 |
