ARALKYLAMINES IN RACEMIC OR OPTICALLY ACTIVE FORM OF PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR PREPARING THEREOF Russian patent published in 1995 - IPC

FIELD: medicine. SUBSTANCE: the product includes aralkylamines of the formula I wherein is 0 or 1; Z is carbonyl or CH(OH); X and Y, the same or different, are halogen, trifluoromethyl, C₁-C₃-alkyl, hydrogen; R-n or i-(C₁-C₆)-alkyl or C₃-C₆-cycloalkyl, hydrogen in a racemic or optically active form, with the proviso that when Z is -CH(OH), either in the form of a mixture or a pure disteriomer, expect for racemates of said derivatives in which X is n-CL; Y is H, Z is -CO-; n is O; R is methyl, or pharmaceutically an amino group to the corresponding derivative using ammonium acetate in the presence of sodium boron hydride or sodium cyanoboron hydride followed by oxidation (if Z is -CH(OH)) to carbonyl or by reduction of carbonyl to CH(OH) and recovery of the desired product in the form of a free base, a desired salt, in the form of racemate or an optically active antipode. The structure of the formula 1:. EFFECT: improved aralkyl amine derivatives and improved preparation process. 3 cl, 2 tbl