PHENYLETHYL- AND PHENYLPROPYLAMINE COMPOUNDS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL PREPARATION Russian patent published in 1999 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes the novel compounds of the formula (1) where Z means saturated or unsaturated chain consisting of 3-6 carbon atoms; m = 2 or 3; R₁ means hydrogen atom or linear or branched C_1-4-alkyl; R₂, R₃ and R₁₃ are located in ortho-, meta- or para-position of phenyl ring and they are similar or distinct and are taken from the following groups: H, OH, OR₁₄, halogen atom, CO₂R₉, CN, where R₉, R₁₂ and R₁₄ mean linear or branched C_1-4-alkyl; R₁₀ and R₁₁ are similar or distinct and mean hydrogen atom or linear or branched C_1-6-alkyl where R means the group of the formula (Ia) where R₄ and R₅ are similar or distinct; when they are distinct then mean hydrogen atom, linear or branched C_1-5-alkyl or substituted or unsabstituted cycloalkyl; when they are similar then mean linear or branched C_1-5-alkyl or R₄ and R₅ in common form the group -(CH₂)n₁- where n₁ = 3-7, or the formula (2) where R₆ means hydrogen atom or linear or branched C_1-6-alkyl and R₇ means substituted or unsubstituted cycloalkyl or R₆ and R₇ in common form the group -(CH₂)n₂- where n₂ = 3-6, or the formula (3) where W means optional substituted carbocyclic ring (or rings) or optional substituted methylene group and R₈ means linear or branched C_1-5-alkyl or phenyl; n₃ = 0-2, or the formula (4) where W means optional substituted carbocyclic ring (rings) or optional substituted methylene group and n₄ = 1 or 2 in racemic or optically active form, or their pharmaceutically acceptable salts. Invention describes a method of synthesis of the above indicated compounds and a pharmaceutical preparation based on compounds of the formula (1). The novel compounds can be used for treatment of patients with psychiatric disorders, for example, schizophrenia and other psychosis, pathological fear, depression and circular psychosis. EFFECT: improved method of synthesis, antipsychotic activity of compounds. 12 cl, 1 tbl, 49 ex