FIELD: organic chemistry. SUBSTANCE: product: derivatives of benzoylbenzenepropanoic acid of the general formula where R1 has similar or different meaning, hydrogen, C1-C3-alkyl; p = 4-6; y - simple bond or -C= C; Z - phenyl, phenyl substituted with halogen or C1-C3-alkoxygroup, or C1-C3-alkyl - S-group. Reagent 1: where R1-C1-C3-alkyl. Reagent 2: X-/CH2/pY-Z where X - chlorine, bromine, iodine, mesilate; p, Z, Y as indicated meanings. Reaction conditions: reagent 1 is treated with reagent 2 in the presence of base, and obtained product is isolated, or compound of the formula (I) where R - C1-C3-alkyl if necessary is subjected for alkaline hydrolysis obtaining compounds of the formula (I) where both R mean H. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 tbl
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Authors
Dates
1995-06-09—Published
1990-12-19—Filed