FIELD: chemistry. SUBSTANCE: product: mutilin derivatives. Reagent 1: aminomutilin. Reagent 2: D-valine which is protected preliminary with enamine and activated with carboxylic acid mixed anhydride. Reaction conditions: in the medium of tert.-butylmethyl ester, at temperature from -20 C to 0 C. Reagent 3: Daine salt. Reagent 4: hydrochloric acid. Reaction conditions: temperature is 10-50 C. Both stages were performed in a single reactor. EFFECT: improved method of synthesis.
| Title | Year | Author | Number |
|---|---|---|---|
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|
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| ANTIBACTERIAL SUBSTITUTED 7-ACYLAMINO-3-(METHYL-HYDRAZONO)-METHYLCEPHALOSPORINS, METHOD OF THEIR PREPARING, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, INTERMEDIATE COMPOUNDS AND METHOD OF TREATMENT OF DISEASES CAUSED BY MICROORGANISMS | 1998 |
|
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| PREPARATION OF CEPHOTAXIME AND SODIUM SALT OF CEPHOTAXIME | 1995 |
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|
RU2183212C2 |
| 0 |
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SU523632A3 | |
| 0 |
|
SU240565A1 |
