FIELD: chemistry. SUBSTANCE: product: mutilin derivatives. Reagent 1: aminomutilin. Reagent 2: D-valine which is protected preliminary with enamine and activated with carboxylic acid mixed anhydride. Reaction conditions: in the medium of tert.-butylmethyl ester, at temperature from -20 C to 0 C. Reagent 3: Daine salt. Reagent 4: hydrochloric acid. Reaction conditions: temperature is 10-50 C. Both stages were performed in a single reactor. EFFECT: improved method of synthesis.
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0 |
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Authors
Dates
1995-06-27—Published
1990-10-02—Filed