DERIVATIVES OF THIENYLHYDROXYALKYLAMINE OR THEIR PHARMACEUTICALLY COMPATIBLE ACID ADDITIVE SALTS Russian patent published in 1995 - IPC

Abstract RU 2027716 C1

FIELD: organic chemistry. SUBSTANCE: product: 5-derivatives of thienylhydroxyalkylamine of the formula (I) where R - hydrogen or group -O-CH₂-CH₂-NR₁R₂ at R₁, R₂ - alkyl or together with nitrogen form pyrrolidinyl-group, n = 1-5. Reagent 1: corresponding derivative of hydroxythienyl. Reagent 2: corresponding amine. Reaction conditions: in the presence of strong base in inert organic solvent. Synthesized compounds were used in medicine as antiarrhythmic agents. EFFECT: improved method of synthesis.

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RU 2 027 716 C1

Authors

Diter Binder[At]

Gerkhard Grajer[At]

Frants Rovenski[At]

Fridrikh Khillebrand[At]

Dates

1995-01-27—Published

1990-05-14—Filed