BENZISOTHIAZOLE- OR BENZISOXAZOLE-3-CARBOXAMIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIPSYCHOTIC ACTIVITY Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: benzisothiazole- or benzisoxazole-3-carboxamides of the formula (I) where R₁ H or lower alkyl; R₂ lower alkyl or a group of the formulas (II) , (III) , (IV) , (V) , (VI) , (VII) , (VIII) , (IX) where A lower alkylene, a group of the formula -CH₂CH=CH-CH₂ or ; X O or S; W N or group CH; Z H, lower alkoxy-group or halogen, and unbroken line indicates the place of group addition to the defined formula member, or their pharmaceutically acceptable salts and pharmaceutical composition with appropriate carrier containing 1-360 mg compound (I) per a single dose. Compounds (I) were synthesized by interaction of compound (X) where R₂-Cl - Cl, Br, J or group OSO₂R₆ where R₆ alkyl, phenyl or tolyl with compound of the formula (XI) or by interaction of compound of the formula (XII) where Hal Cl or Br with compound of the formula (XIII) . Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 7 cl, 2 tbl