METHOD FOR PRODUCTION OF SUBSTITUTED N-(ARYL OXYALKYL)-HETEROARYL PIPERIDINE OR HETEROARYL PIPERAZINE Russian patent published in 1996 - IPC

FIELD: medicine. SUBSTANCE: desired product has formula given in specification where X is O, S, NH, NR"; Y is H, Cl, F, Br, J, R" is C(O)Ph; Z is CH, N; n= 2-5; R is H, OH, (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy, Br, CN, C₁-C₆-alkyl-S, (C₁-C₆)-alkyl C(O), C(O)NH₂, (C₁-C₆)-alkyl NH, (C₁-C₆)-alkyl C(O)NH, C(O)Ph, (C₁-C₆)-alkyl CH (OR′), where R′ is H, (C₁-C₆)-alkyl C(O), (C₁-C₆)-alkyl; m= 1-3 proviso that Z is not N if X=S, R=H. Derivatives of heteroaryl piperidine or heteroaryl piperazine where X, Y and Z being as mentioned above are used as reagent 1. (Hal(CH₂)_nO)(R)_mC₆H_5-m where n,m and R being as mentioned above is used as reagent 2. Reaction is carried out at temperature from 50 C to fractionation point in the medium of inert solvent. The process takes place in the presence of acid receptor, it is followed by reduction if it is necessary. Then treatment with anhydride of alkane acid or interaction with strong base followed by interaction with (C₁-C₆) alkyl halide or interaction with benzoyl halide is carried out. EFFECT: improves efficiency of the method. 14 cl, 3 tbl