FIELD: organic chemistry. SUBSTANCE: product: (1′R, 5′R)-3′-aza-1′-(2-amino-1,6-dihydro -6-oxopurinyl-9)-3′-deoxy-3′-[5-(dimethylamino) naphthalene-1-sulfamido] hexopyranosyl-6′- [4-fluorosulfonyl)benzoate] yield is 42% empirical formula is C29H29FN8O8S2, m. p. is 170-172 C (with decomposition). Product: (1′R, 5′R)-3′-aza-1′- (2-amino-1,6- dihydro-6-oxopurinyl -9)-3′-deoxy-3′- [5-(dimethylamino) naphthalene-1-sulfamido] hexopyranosyl-6′- [4-bromomethyl)benzoate] yield is 51% empirical formula is C30H31BrN8O8S, m. p. is 176-178 C (with decomposition). Product: (1′R, 5′R)-3′-aza-1′- (2-amino-1,6-dihydro -6-oxopurinyl-9)-3′ -deoxy-3′- (2-hydroxybenzamido)hexopyranozyl -6′-[4-(fluorosulfonyl)benzoate] yield is 38% empirical formula is C24H22FN7O10S, m. p. is 160 C (with decomposition). Product: (1′R, 5′R)-3′-aza-1′- (2-amino-1,6-dihydro -6′-oxopurinyl -9-3′-deoxy-3′- (2-hydroxybenzamido)hexopyranosyl -6′-[4-(bromomethyl)benzoate] yield is 43% empirical formula is C25H24BrN7O8, m. p. is 168-170 C (with decomposition). Synthesized compounds were used as specific irreversible fluorescent inhibitors of RNA-polymerase. EFFECT: improved method of synthesis. 1 tbl
| Title |
Year |
Author |
Number |
| AZIDONAPHTHALENE -1-SULFONYLHYDRAZINES AS SEMIPRODUCTS FOR SYNTHESIS OF (1′R,5′R)-3′-AZA-1′- (2-AMINO-1,6-DIHYDRO-6-OXOPURINYL-9)-- 3′-DEOXY- 3′-(AZIDONAPHTHALENE-1-SULFAMIDO)-HEXOPYRANOSY- L-6′- TRIPHOSPHATES TRILITHIUM SALTS AS SPECIFIC PHOTOACTIVATED IRREVERSIBLE RNA-POLYMERASE INHIBITORS |
1991 |
- Khropov Ju.V.
- Mishin A.A.
- Seliverstov V.O.
- Kulagin S.V.
- Kochetkov S.N.
|
RU2036903C1 |
| (1′R,5′R)-3′-AZA-1′- (2-AMINO-1,6-DIHYDRO-6- OXOPURINYL-9)-3′-DEOXY- 3′- (AZIDONAPHTHALENE-1-SULFAMIDO) -HEXOPYRANOSYL-6′-TRIPHOSPHA- TE TRILITHIUM SALTS AS SPECIFIC PHOTOACTIVATED IRREVERSIBLE RNA-POLYMERASE INHIBITORS |
1991 |
- Khropov Ju.V.
- Mishin A.A.
- Seliverstov V.O.
- Kulagin S.V.
- Kochetkov S.N.
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| 4-AZIDONAPHTHALENE-1-SULFONYLCHLORIDE AS SEMIPRODUCT FOR SYNTHESIS OF (1′R,5′R) -3′-AZA-1′ -(2-AMINO-1,6-DIHYDRO-6-OXOPURINYL-9)-- 3′-DEOXY-3′- (4-AZIDONAPHTHALENE-1-SULFAMIDO) HEXOPYRANOSYL-- 6′-TRIPHOSPHATE TRILITHIUM SALT AS SPECIFIC PHOTOACTIVATED IRREVERSIBLE RNA-POLYMERASE INHIBITOR |
1991 |
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1997 |
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| LITHIUM SALTS OF (I'R,5'R)-3'-AZA-3'-(AZIDONAPHTHALINE-1- SULFAMIDO)-1'-(6-AMINOPURINYL-9)-3'-DEOXYHEXOPIRANOZYL- 6'-DI-OR TRIPHOSPHATES AS SPESIFIC PHOTOACTIVATED IRREVERSIBLE INHIBITORS OF Na, K-ADENOSINE TRIPHOSPHATASE |
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