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2 039 746

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C1

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IPC

(21) (22)

Application

92015764/04, 1992-12-30

(22)

Actual filing date

1992-12-30

(45)

Published

1995-07-20

(72)

Inventor

Oganesjan Eh.T.Tuskaev V.A.Sarkisov L.S.Ivashev M.N.

(73)

Holder

Pjatigorskij Farmatsevticheskij Institut

2-HYDROXY-5-BROMOBENZOYL -6′- FLUOROCHROMONE -3′-AL)-HYDRAZONE SHOWING COAGULATING ACTIVITY Russian patent published in 1995 - IPC

Abstract RU 2039746 C1

FIELD: organic chemistry. SUBSTANCE: product: 2-hydroxy-5-bromobenzoyl -6′-fluorochromone-3′-al)-hydrazone, empirical formula is C17H10BrFN2O4., m. p. is 257-258 C. Proposed compound at the dose 10 mg/kg decreases blood clotting time up to 100 ± 6,5 s, M ± м., LD50 is 1800 mg/kg. Reagent 1: 6-fluorochromone-3-aldehyde. Reagent 2: 5-bromosalicylic acid hydrazide. Process condition: heating on the water bath for 3 h, yield is 73% Synthesized compound is used in medicine. EFFECT: increased yield of the end product. 1 tbl

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RU 2 039 746 C1

Authors

Oganesjan Eh.T.

Tuskaev V.A.

Sarkisov L.S.

Ivashev M.N.

Dates

1995-07-20—Published

1992-12-30—Filed

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