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2 049 091

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C1

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IPC

(21) (22)

Application

5027488/04, 1992-02-14

(22)

Actual filing date

1992-02-14

(45)

Published

1995-11-27

(72)

Inventor

Oganesjan Eh.T.Kodonidi I.P.Saraf A.S.Rjabukhin Ju.I.

(73)

Holder

Pjatigorskij Farmatsevticheskij Institut

DERIVATIVE OF 4-OXO-1,4-DIHYDROPYRIMIDINE SHOWING ANTIALLERGIC ACTIVITY Russian patent published in 1995 - IPC

Abstract RU 2049091 C1

FIELD: organic chemistry. SUBSTANCE: products: derivatives of 4-oxo-1,4-dihydropyrimidine of the formula (I) : a) empirical formula is C21H2ON4O4S, yield is 69% m. p. is 255-257 C; b) empirical formula is C19H16N4O, yield is 73% m. p. is 179-180 C. Reagent 1: N-acetyl-2-phenylacetoacetamides of the formula (II): O/double bond/CR′-CH(phenyl)-C(O)-NH-CR″/double bond/O where R′ and R″ as indicated below. Reagent 2: aminoheteryls of the formula (III): NH-Het where Het - as indicated below. Reaction conditions: boiling in mixture of dimethylformamide and glacial acetic acid for 1 hr. Synthesized compounds were used in chemical-pharmaceutical industry since they show antiallergic action. a) , R1-R2-C2H5; b) , R1-R2-CH3. EFFECT: improved method of synthesis. 1 tbl

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RU 2 049 091 C1

Authors

Oganesjan Eh.T.

Kodonidi I.P.

Saraf A.S.

Rjabukhin Ju.I.

Dates

1995-11-27—Published

1992-02-14—Filed

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