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2 039 747

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C1

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IPC

(21) (22)

Application

92015767/04, 1992-12-30

(22)

Actual filing date

1992-12-30

(45)

Published

1995-07-20

(72)

Inventor

Oganesjan Eh.T.Tuskaev V.A.Saraf A.S.Sarkisov L.S.

(73)

Holder

Pjatigorskij Farmatsevticheskij Institut

DERIVATIVES OF 3-(6′- METHOXYCHROMONYL-3′) -2- ACETYLPROPENE-2-CARBOXYLIC ACID SHOWING ANTIALLERGIC ACTIVITY Russian patent published in 1995 - IPC

Abstract RU 2039747 C1

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 3-(6′-methoxychromonyl-3′)-2-acetylpropene-2-carboxylic acid, i. e. ethyl ester of 3-(6′-methoxychromonyl-3′)-2-acetylpropene-2-carboxylic acid, empirical formula is C17H16O6, m. p. is 206 C and o-aniside of 3-(6′-methoxychromonyl-3′)-2-acetylpropene-2-carboxylic acid, empirical formula is C22H19NO6, m. p. is 263 C. Synthesized compounds inhibit reactions of passive skin anaphylaxis by 32.2-52.9% Reagent 1: 6-methoxychromone-3-aldehyde. Reagent 2: acetoacetic ester or o-anisidide of acetoacetic acid. Process conditions: in pyridine medium, at heating. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 1 tbl

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RU 2 039 747 C1

Authors

Oganesjan Eh.T.

Tuskaev V.A.

Saraf A.S.

Sarkisov L.S.

Dates

1995-07-20—Published

1992-12-30—Filed

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