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1 329 141

(13)

A1

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IPC

(21) (22)

Application

3853061/04, 1985-01-28

(22)

Actual filing date

1985-01-28

(45)

Published

1995-02-27

(72)

Inventor

Savel'Ev E.A.Loseva L.D.Kovaleva M.P.

METHOD OF PREPARING CEPHALOSPORIN C ZINC SALT Russian patent published in 1995 - IPC

Abstract SU 1329141 A1

FIELD: heterocyclic compounds. SUBSTANCE: cephalosporin C is prepared by its adsorption from native solution on the nonionogenic sorbent following its desorption of cephalosporin C from sorbent with aqueous-organic solvent. Then cephalosporin C is desorbed from eluate on the anionic-exchange resin - cross-linked copolymer of N-aminoethylacrylamide and divinyl ester of ethylene glycol of the general formula where K - NH2-C2H4-C(O)- ;; M - ; R - (CH2)2; ratio m:n = 1:(13.3-32.3); mol. mass is (1-100) x 1012. Precipitation is carried out with zinc salt from cephalosporin C solution prepared immediately at cephalosporin C desorption from anionite with aqueous solution of electrolyte. Yield of cephalosporine C is increased from 69 to 72-75%, mass part of impurities is decreased from 15.4 to 3.8, consumption of organic solvent is decreased by 2-fold. EFFECT: improved method of cephalosporin C preparing. 1 tbl

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SU 1 329 141 A1

Authors

Savel'Ev E.A.

Loseva L.D.

Kovaleva M.P.

Dates

1995-02-27—Published

1985-01-28—Filed

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