DERIVATIVES OF CYCLIC AMIDE OR THEIRS PHARMACOLOGICALLY ACCEPTABLE SALT SHOWING ANTIACETYLCHOLONINE ESTERASE ACTIVITY Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: product - derivatives of cyclic amide of the general formula I R₁-(CH₂)_n-Z, where R₁ - one of the following group: 2H-3,4-dihydro-1,3-benzoxazine-2-one, 2H-3,4-dihydro-1,3-benzoxazine-2,4-dione, 1,2,3,4-tetrahydroquinazoline-2,4-dione, 2,2,3,4-tetrahydroquinazoline-2-one, 1,2,3,4-tetrahydropyrido(3,2-d)pyrimidine-2,4-dione, 1,2,3,4-tetrahydropyrido(3,2-d)pyrimidine-2-one, 1,2,3,4-tetrahydropteridine-2,4-dione, pyrrolidine-2-one, 1,2,3,4-tetrahydropteridine-2-one, 5H-6,78,9-tetrahydropyrido(3,2-b)azepine-6-one, 9H- 5,6,7,8-tetrahydropyrido(3,2-b)azepine-8-one, 2H-3,4-dihydropyrido(3,2-e)-1,3-azepine-2-thione or -2-one, pyrrolidine(3,4-b)pyrazine-5-one, 1H-2,3,4,5-tetrahydroazepine (3,2-b)indole-2-one, 8H-4,5,6,7-tetrahydroazepine(3,2-b)- thiophene-7-one, 4H-pyrazolo(5,4-e)benzazepine-9-one, isoindoline-1,3-dione, benzoxazoline-2-one, possibly, substituted with lower alkyloyloxy, halide, nitro, carboxy, benzoyl or benzyl; n = 1-6; Z - group of the general formula 2 or 3 , where R₂ - phenyl, possibly, haloidphenyl, C₅-C₆-cycloalkyl or pyridine, dioxolane, furane, tetrahydrofurane, methylfurane or thiophene radical; m = 1-3; R₃ lower alkyl; R₄ phenyl or dioxolane, furane or thiophene radical; p = 1 at condition that at R₁ - 1,2,3,4-tetrahydroquinazole-2-one or 2,4-dione R₂ and R₄ are neither phenyl nor halogenphenyl, or theirs pharmacologically acceptable salts. Synthesized compounds are used in medicine. EFFECT: enhanced activity of compounds indicated above. 1 tbl