FIELD: organic chemistry. SUBSTANCE: product - derivatives of benzodiazepine of the general formula R1 (1), where X- -CH2 - phenyl possibly substituted with fluorine; X - =CHR3 or R3-C1-C4, where R2-alkyl; R2 - 2-indolylcarbonyl, phenyl(lower)alkenoyl, which can be substituted with amino-group; or 
- phenylcarbamoyl, when can be substituted with halogen or lower alkoxy-group, or theirs pharmaceutically acceptable salts. Preferable product: (3S) - 1 - (2 - fluorophenyl) - 3,4,6,7 - tetrahydro - 3 - (2 - indolylcarbonylamino) - 4 - oxopyrrolo(3,2,1 - j, k)(1,4) - benzodiazepine. Synthesized compounds are used in medicine at gastroenteric diseases (vomiting, pancreatitis). EFFECT: enhanced effectiveness of synthesized benzodiazepines. 2 cl, 1 tbl
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