PROCESS FOR PREPARING CRYSTALLINE 9-DEOXO- 11-DEOXY -9,11-1 (IMINO[2- (2-METHOXYETHOXY) ETHYLIDENE) OXY-1) ERYTHROMYCIN Russian patent published in 1995 - IPC

FIELD: medicine. SUBSTANCE: a process for synthesizing a macrolide dinitromycin antibiotic in crystalline form. The process is carried out in one reaction vessel with the result that acetal dissolved in aqueous acetonitrile in the presence of an acid catalyst is hydrolyzed to form a very similar semiacetal which is then reacted directly with erythromycil amine to form crystalline dinitroomycin. The acid catalyst is preferably sulfuric acid, methane-sulfonic acid, para-toluene sulfonic acid, hydrochloric acid or camphosulfonic acid. The acetal to erythromycilamine molar ratio is (1.5-3.5): 1. The amount of catalyst in molar equivalents to erythromycil amine is less than 0.2, preferably 0.04. EFFECT: more efficient preparation process. 8 cl, 2 tbl