PROCESS FOR PREPARING R-(Z)-7-(2-AMINO-2- CARBOXYETHYL) THIO-2-(2,2 -DIMETHYLCYCLOPROPYLCARBONYL) AMINO-2-HEPTENIC ACID Russian patent published in 1995 - IPC

FIELD: chemical industry. SUBSTANCE: the product: R-(Z)-7-(2-amino-2-carboxyethyl)thio-2-(2,2-dimethylcyclopropylcarbonyl)amino-2-heptenic acid of the emperical formula: C₁₆H₂₅N₂O₅S, the yield is 50% Reagent 1: lower alkyl (methyl)ester of 7- cloro-2-aminoheptanic acid. Reagent 2: dimethylcyclopropanecarboxylic acid chloride. Conditions of reaction 1: in the presence of triethylamine in absolute ether at 0 C for 1 hour and at room temperature for 24 hours and at 30-35 C for 2 hours. Reagent 3: N-(dimethylcyclopropylcarbonyl)-7-chloro-2-3-aminoheptanic acid ester. Reagent 4: a dehydrogenating agent. Conditions of reaction 2: in the presence of tert-butylhypochlorite and a sodium methylate solution in absolute methanol. Reagent 5: (Z)-N-(dimethylcyclopropylcarbonyl)-7-chloro-2-amino-2- heptenic acid. Reagent 6: alkali metal hydroxide. Conditions of reaction 3: NaOH in methanol at room temperature. Reagent 7: (Z)-N(dimethylcyclopropylcarbonyl)-7-chloro-2-amino- 2-heptenic acid. Reagent 8: cysteine. Reaction conditions of reaction 4: an alkaline-alcoholic solution in the presence of 1 to 10% EFFECT: more efficient preparation process. 2 cl