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2 046 796

(13)

C1

(51)

IPC

(21) (22)

Application

93026842/04, 1993-05-24

(22)

Actual filing date

1993-05-24

(45)

Published

1995-10-27

(72)

Inventor

Pronina G.A.Tjuljaev I.I.Dudov E.A.

(73)

Holder

Aktsionernoe Obshchestvo Otkrytogo Tipa

METHOD OF ISOLATION AND PURIFICATION OF 10-DIALKYLAMINOALKYLPHENOTHIAZINE HYDROCHLORIDE Russian patent published in 1995 - IPC

Abstract RU 2046796 C1

FIELD: organic chemistry. SUBSTANCE: product: 10-dialkylaminoalkylphenothiazine hydrochloride of the formula (I) where R, R′ R″ have corresponding meanings. Method of synthesis involves treatment of base solution in organic solvent with acetic acid aqueous solution at pH 5.5-5.7 followed by aqueous layer separation, water azeotrope distillation off with organic solvent. Then prepared product is treated with isopropanol, hydrogen chloride at pH 3.3-3.5. Solvent mixture is distilled off and the end 10-dialkylaminoalkylphenothiazine hydrochloride is isolated by crystallization. The latter is purified by crystallization from the mixture of toluene and lower alkyl alcohol. EFFECT: improved method of isolation and purification. 8 dwg, 1 tbl

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RU 2 046 796 C1

Authors

Pronina G.A.

Tjuljaev I.I.

Dudov E.A.

Dates

1995-10-27—Published

1993-05-24—Filed

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