METHOD OF SYNTHESIS OF PEPTIDE DERIVATIVES OR THEIR PHYSIOLOGICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: products: derivatives of peptides containing natural, synthetic amino acids, isoamino acids, imino acids and substituents such as: tetrahydroquinoline, pyridyl, indolyl, benzyl (substituted and nonsubstituted). naphthyl, cyclohexyl and physiologically acceptable salts also. Reagent 1: fragment containing terminal carboxy-group or its reactive derivative. Reagent 2: corresponding fragment containing free amino-group. Synthesis is carried out in solution in the presence of condensing agent using protective groups followed by if necessary deblocking and conversion of free base to its physiologically acceptable salts. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 3 cl