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2 049 471

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C1

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IPC

(21) (22)

Application

92012910/14, 1992-12-21

(22)

Actual filing date

1992-12-21

(45)

Published

1995-12-10

(72)

Inventor

Karjakin A.V.Vasil'Ev G.S.Jusupov V.G.Mel'Nikov V.N.

(73)

Holder

Nauchno-Proizvodstvennoe Ob"Edinenie

METHOD OF PREPARING BRAIN TISSUE HYDROLYZATE "CEREBROLYZATE" Russian patent published in 1995 - IPC

Abstract RU 2049471 C1

FIELD: drug production. SUBSTANCE: homogenate of brain cortex is subjected for enzymatic hydrolysis at pH 6.8-8.4 for 4-5 hr. Then mill cake is separated by filtration through membrane filter at pore size 0.22-0.5 mcm, and proteins and peptides were separated by two-stage ultrafiltration through membrane at threshold retention of substances 30-50 kDa and 5-15 kDa. Mixture is evaporated under vacuum (concentration), preserving agent is added 0.3% phenol followed by sterile filtration through membrane at pore size 0.2-0.32 mcm. EFFECT: simplified technology, high clinic activity of preparation. 1 tbl

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RU 2 049 471 C1

Authors

Karjakin A.V.

Vasil'Ev G.S.

Jusupov V.G.

Mel'Nikov V.N.

Dates

1995-12-10—Published

1992-12-21—Filed

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