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2 049 472

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C1

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IPC

(21) (22)

Application

92012911/14, 1992-12-21

(22)

Actual filing date

1992-12-21

(45)

Published

1995-12-10

(72)

Inventor

Karjakin A.V.Vasil'Ev G.S.Jusupov V.G.Mel'Nikov V.N.Kulagin V.F.

(73)

Holder

Nauchno-Proizvodstvennoe Ob"Edinenie

METHOD OF PREPARING BRAIN TISSUE HYDROLYZATE "CEREBROLYZATE" Russian patent published in 1995 - IPC

Abstract RU 2049472 C1

FIELD: drug production. SUBSTANCE: homogenate of brain cortex is subjected for enzymatic hydrolysis at pH 6.8-8.4 for 4-5 hr. Then proteins were separated by alcohol precipitation, prepared hydrolyzate is filtered successively through membrane filters at pore size 0.22-0.5 mcm at threshold retention of substances 5-15 kDa. Alcohol and water were distilled off, preserving agent is added 0.3% phenol followed by sterile filtration through membrane at pore size 0.2-0.32 mcm. EFFECT: simplified technology, high clinic effectiveness of preparation. 1 tbl

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RU 2 049 472 C1

Authors

Karjakin A.V.

Vasil'Ev G.S.

Jusupov V.G.

Mel'Nikov V.N.

Kulagin V.F.

Dates

1995-12-10—Published

1992-12-21—Filed

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