METHOD OF SYNTHESIS OF 2-METHOXYMETHYLPENEMS Russian patent published in 1995 - IPC

Abstract RU 2049786 C1

FIELD: organic chemistry. SUBSTANCE: product: compound of the general formula (II) where R hydrogen atom or hydroxyl-protecting group is subjected for interaction with oxalylhalogenide in the presence of organic or inorganic base. Synthesized compound of the general formula (III) where R has indicated above meanings, and X halogen atom is treated with compound of the general formula (IV) in the presence of organic or inorganic base followed by cyclization of prepared compound of the general formula (V) where R has indicated meanings in the presence of trialkylphosphite and the end product (I) isolation. If necessary, hydroxyl-protecting group in synthesized compound is removed. EFFECT: improved method of synthesis. 3 cl

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RU 2 049 786 C1

Authors

Ehttore Perrone[It]

Marko Al'Pegani[It]

Franko Dzarini[It]

Dzhuzeppe Madzini[It]

Dzhovanni Francheski[It]

Dates

1995-12-10Published

1990-07-03Filed