FIELD: organic chemistry. SUBSTANCE: product: derivatives of the formula (I) where one or two carbon atoms of methylene groups can be substituted with alkyl, (C1-C4)-alkoxy-group-(C1-C4), or the same carbon methylene groups can be joined by bridge with alkane-(C2-C4)-diyl radical; X CH or N, every of m and n independently each of other means 1, 2, 3 and the sum m + n 3, 4 or 5; R1 hydrogen, haloid, alkyl-(C1-C4); every of R2 and R3 independently of other means hydrogen or (C1-C4)-alkyl. Alk - alkane-(C1-C4)-diyl, every of R4 and R5 independently of other means hydrogen or haloid, (C1-C4)-alkyl, and He is selected from the group: oxadiazole, oxazole, thiazole, thiadiazole. Reagent A (): amine. Reagent B (): pyridazine derivatives, w splitting group. Process is carried out in reactive inert solvent in the presence of the base. Heterocyclic derivatives are amines of the formula A. Antiviral composition has inert solvent and pyridazineamine derivatives of the formula (I) as active substance at concentration 0.05-15 wt. -% Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 5 tbl
Authors
Dates
1995-12-27—Published
1990-12-25—Filed