BENSENEACETAMIDE DERIVATIVE, METHODS OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes use of compound as drug having formula: or pharmaceutically acceptable acid addition salt thereof or stereochemical isomeric form thereof in which R¹ and R² each is independently hydrogen, C_1-6 alkyl or C_3-6 cycloalkyl; or R¹ and R² together which nitrogen atom to which said R¹ and R² are attached form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or C_1-4 alkyl piperazinyl; X is oxygen or sulfur; R³ is hydrogen or C_1-6 alkyl; R⁴, R⁵ и R⁶ are each independently hydrogen, halogen, C_1-6 alkyl, C_1-6 alkoxy, nitro, trifluoromethyl, cyano, aminomethyl, cyano, aminomethyl, carboxy, C_1-4 alkoxycarbonyl, C_1-4 alkylcarbonyl, aminocarbonyl or hydroxy; R⁷ is hydrogen or halogen; and R⁸, R⁹ and R¹⁰ are each independently hydrogen, halogen, C_1-6 alkyl, C_1-6 alkoxy, nitro, hydroxy, trifluoromethoxy, 2,2,2- trifluoroethoxy (trifluoromethyl) carbonyl, aminocarbonyl (cyclopropyl) carbonyl or C_1-6 alkyl-(0=Y)-in which Y represents =O, =H, -OH, N-OCH₃, N-NH₂ or N-N(CH₃)₂ provided that R¹ is other than n-propyl when R², R³, R⁴, R⁵, R⁶, R⁷, R⁹ and R¹⁰ are hydrogen, R⁸ is 4-ethoxy and X is oxygen, and X is other than sulfur when R¹, R², R³, R⁶, R⁷, R⁸, R⁹ and R¹⁰ are hydrogen, and R⁴ and R⁵ are 3,4 dimethoxy group. EFFECT: improved properties of the pharmaceutical composition. 15 cl, 3 tbl