BENSENEACETAMIDE DERIVATIVE, METHODS OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

Abstract RU 2087465 C1

FIELD: pharmaceutical industry. SUBSTANCE: present invention describes use of compound as drug having formula: or pharmaceutically acceptable acid addition salt thereof or stereochemical isomeric form thereof in which R1 and R2 each is independently hydrogen, C1-6 alkyl or C3-6 cycloalkyl; or R1 and R2 together which nitrogen atom to which said R1 and R2 are attached form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or C1-4 alkyl piperazinyl; X is oxygen or sulfur; R3 is hydrogen or C1-6 alkyl; R4, R5 и R6 are each independently hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, trifluoromethyl, cyano, aminomethyl, cyano, aminomethyl, carboxy, C1-4 alkoxycarbonyl, C1-4 alkylcarbonyl, aminocarbonyl or hydroxy; R7 is hydrogen or halogen; and R8, R9 and R10 are each independently hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, hydroxy, trifluoromethoxy, 2,2,2- trifluoroethoxy (trifluoromethyl) carbonyl, aminocarbonyl (cyclopropyl) carbonyl or C1-6 alkyl-(0=Y)-in which Y represents =O, =H, -OH, N-OCH3, N-NH2 or N-N(CH3)2 provided that R1 is other than n-propyl when R2, R3, R4, R5, R6, R7, R9 and R10 are hydrogen, R8 is 4-ethoxy and X is oxygen, and X is other than sulfur when R1, R2, R3, R6, R7, R8, R9 and R10 are hydrogen, and R4 and R5 are 3,4 dimethoxy group. EFFECT: improved properties of the pharmaceutical composition. 15 cl, 3 tbl

Similar patents RU2087465C1

Title Year Author Number
SUBSTITUTED DERIVATIVES OF DIAMINO-1,3,5-TRIAZINE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING 1997
  • Kukla Majkl Dzhozef
  • Ljudovisi Donal'D V.
  • Zhansen Pol' Adrian Zhan
  • Geres Jan
  • Merel' Anri Ehmil' Lodevijk
RU2186774C2
PHARMACEUTICAL COMPOSITION INHIBITING 5-LIPOXYHENASE, 4-(4-PHENYL-1-PIPERAZINYL) PHENYL DERIVATIVE AND METHOD FOR ITS PRODUCTION 1989
  • Zhan P'Er Frans Van Vov[Be]
  • Jan Kheres[Nl]
  • Leo Jakobus Jozef Bakks[Be]
RU2107064C1
TETRAHYDROIMIDAZO-[1,4]-BENZODIAZEPINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR STEREOISOMERS, A METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND ANTIVIRAL COMPOSITION 1992
  • Mikhail Zhozef Kjukla[Us]
  • Anri Zhozef Breslin[Us]
  • Al'Fons German Margarita Rajmaker[Be]
  • Zhozefjus Ljudovikjus Jubertjus Van Gelder[Be]
  • Pol' Adrian Zhan Zhansen[Be]
RU2099341C1
DERIVATIVES OF PYRAMIDINE-4-ONE OF THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND SEROTONIN-ANTAGONISTIC, DOPAMINE-ANTAGONISTIC AND ANTIGISTAMINE COMPOSITION ON THEIR BASES 1990
  • Lido Ehdmon Zhozefin Kennis[Be]
  • Jan Vandenberk[Be]
  • Jozef Martin Buj[Be]
RU2028297C1
METHOD OF SYNTHESIS OF DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE, OR THEIR SALTS, OR THEIR STEREOCHEMICALLY ISOMERIC FORM 1990
  • Zhorzh Anri Pol' Van Del'[Be]
  • Frans Marija Al'Fons Van Den Kejbus[Be]
RU2037492C1
N-SUBSTITUTED PIPERIDINYLBENZOATES, THEIR N-OXIDE FORMS, PHARMACEUTICALLY ACCEPTABLE SALTS OF ADDITIVE ACID SALTS AND STEREOCHEMICALLY ISOMERIC FORMS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE SUBSTANCE 1995
  • Zhorzh Ehnri Pol' Van Dal'
  • Zhan-Pol' Rene Mari Andre Bosmans
  • Frans Marija Al'Fons Van Den Kejbus
RU2154064C2
DERIVATIVES OF PHENYLOXOALKYL-(4-PIPERIDINYL)-BENZOATE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF ITS PREPARING AND INTERMEDIATE COMPOUND 1995
  • Zhorzh Ehnri Pol' Van Dal'
  • Zhan-Pol' Rene Mari Andre Bosmans
  • Mark Gustaf Selin Verdonk
RU2154634C2
DERIVATIVES OF 1,2,3,4-TETRAHYDROBENZOFURO[3,2-C]-PYRIDINE, METHODS OF THEIR SYNTHESIS AND COMPOSITIONS BASED ON THEREOF 1998
  • Kennis Ljudo Ehdmond Zhozefin
  • Lav Kristofer Dzhon
  • Bishoff Fransua Pol'
RU2198175C2
DERIVATIVES OF IMIDEAZOQUINAZOLINE SHOWING POSITIVE INOTROPIC AND LUSITROPIC PROPERTIES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND A METHOD OF TREATMENT 1990
  • Ehddi Zhan Ehdgar Frejn[Be]
  • Al'Fons German Margarita Rajmakers[Be]
RU2057753C1
DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE AND PHARMACEUTICAL COMPOSITION 1993
  • Zhorzh Anri Pol' Van Del'[Be]
  • Frans Marija Al'Fons Van Den Kejbus[Be]
RU2108332C1

RU 2 087 465 C1

Authors

Zhorzh Anri Pol' Van Dael[Be]

Mark Gjustaf Selin Verdonk[Be]

Zhan-Pol' Rene Mari Andre Bosman[Be]

Pol' Adrian Zhan Zhanssen[Be]

Dates

1997-08-20Published

1991-07-04Filed