1-AMINONAPHTHALENE-5-SULFAMIDES AS DETECTED GROUPS FOR ANALYSIS OF PROTEASES MIXTURE AND 1-BENZYLHYDROXYCARBONYLAMINONAPHTHALENE-5-SULFAMIDES AS SEMIPRO- DUCTS FOR 1-AMINONAPHTHALENE-5-SULFAMIDES SYNTHESIS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: synthesis of semiproducts is carried out by reaction of 1-carbobenzoxyaminonaphthalene-5-sulfochloride and alkylamine nitrate in the presence of soda in aqueous-dioxane medium at stirring at 60 C. Yield, % ; m. p. C; gross-formula: a) 97; 153-154; C₁₉H₁₈N₂O₄S; b) 98; 146-147; C₂₁H₂₂N₂O₄S; c) 93; 165-167; C₂₄H₂₆N₂O₄S. Synthesis of the end products is carried out by hydrogenation of 1-ben- zylhydroxycarbonylaminonaphthalene-S-p-alkylsulfamide on Pd/C at 25 C with hydrogen at stirring. Process is controlled by thin-layer chromatography. Process is carried out in the medium of dimethylformamide. Yield, % ; m. p. C; gross-formula: a) 98; 200; C₁₁H₁₂N₂O₂S; b) 50; 185; C₁₃H₁₀N₂O₂S; c) 99; 201; C₁₆H₂₀N₂O₂S. Use of new substances enables to increase quantity of simultaneously analyzing proteases and to enhance selectivity of assay. EFFECT: synthesis of new semifinished products, enhanced yields. 4 tbl