METHOD OF SYNTHESIS OF ADAMANTYL-, ADAMANTYLALKYL- OR HOMOADAMANTYLPHOSPHONIC ACID DICHLOROANHYDRIDES Russian patent published in 1996 - IPC

FIELD: organic chemistry. SUBSTANCE: product: dichloroanhydrides of adamantyl-, adamantylalkyl- or homoadamantylphosphonic acids of the formula (I) where a/mnxO, y₁,R₁-hydrogen, lower alkyl, phenyl substituted with methyl, nitro- or methylsulfonic acid; R₂ - hydrogen; b/mnyO, x₁,R₁-hydrogen; R₂ - lower alkyl, phenyl substituted with methyl or bromine; c/nxO, my1, R₁R₂ - hydrogen; R₃ - hydrogen or lower alkyl; R₄ - lower alkyl; d/mxO, ny1, R₁R₂ - hydrogen. Reagent 1: compound of the formula (II) where at mxO, y₁,R₁-hydrogen, lower alkyl, phenyl substituted with methyl, nitro- or methylsulfonic group; R₂ - hydrogen; at myO, x₁,R₁-hydrogen; R₂ - lower alkyl, phenyl substituted with methyl or bromine; at xO, my1, R₁R₂ - hydrogen; R₃,R ₄ - hydrogen or lower alkyl. Reagent 2: trichlorophosphorus. Reaction conditions: process is carried out in trifluoroacetic acid medium at the mole ratio of reagent 1 and 2 and trifluoroacetic acid = 1:(1.5-2.2): (5-10), at 20-80 C. Structure of compounds of the formula I - II is given in description text. EFFECT: improved method of synthesis. 1 tbl