METHOD OF SYNTHESIS OF 5-[3(4)-R-1-ADAMANTYL]-PYRIMIDINES Russian patent published in 1996 - IPC

FIELD: organic chemistry. SUBSTANCE: product: 5-[3(4)-R-1-adamantyl]-pyrimidines of the general formula where R¹, R² - H, lower alkyl, phenyl substituted with CH₃CF₃, Cl-group; R³, R⁴, R⁵ - H, hydroxy-, halide- or amino-group. Method involves interaction of hydroxyadamantanes with pyrimidine bases in trifluoroacetic acid at mole ratio hydroxyadamantane derivative : pyrimidine base : trifluoroacetic acid = 1:1: (6-10), at mixture boiling point. 1-Hydroxyadamantane and 3(4)-substituted 1-hydroxyadamantanes were used as hydroxyadamantane derivatives. 2,4-Dihydroxypyrimidine, or 2,4-dichloropyrimidine, or 2-amino-4,6-didihydroxypyrimidine were used as pyrimidine bases. Synthesized compounds can be used for synthesis of bioactive substances and in medicine. EFFECT: improved method of synthesis.